What DNA files do you accept?

We accept raw data exports from 23andMe (all versions), AncestryDNA, MyHeritage, LivingDNA, and FamilyTreeDNA. Files can be .txt, .csv, .tsv, .zip, or .gz format. Most consumer DNA chips contain 600K–900K variants.

How accurate are polygenic risk scores?

Every score uses peer-reviewed PGS Catalog models selected for report-grade coverage and relevance. Each score shows percentile direction and coverage. With imputation enabled, coverage jumps from ~30% to ~95%, making scores significantly more useful. PRS show relative genetic tendency compared to the population.

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Your DNA file is deleted immediately after analysis completes. All intermediate files are purged within 2 hours. You receive a SHA-256 Data Deletion Certificate proving destruction. We do not store, sell, or share your genetic data.

What’s included in the report?

300+ carefully curated polygenic risk scores across cardiovascular, cancer, metabolic, neurological, immune, and trait categories, surfaced after coverage and quality filtering. ClinVar variant scanning, pharmacogenomics, protein pathway context, training and diet guidance, and downloadable evidence packs are delivered as an interactive HTML report.

Consumer DNA chips only test ~700K positions out of your 3 billion base pairs. Imputation uses a reference panel to infer additional positions that were not directly measured. This improves polygenic risk score coverage, especially when key model variants are not present on the original chip.

How long does analysis take?

Without imputation: 2–5 minutes. With imputation enabled: 15–45 minutes depending on server load. You’ll receive your report by email when it’s ready.

Is this a medical diagnostic tool?

No. Helix Sequencing is for research and educational purposes. Results should be discussed with a healthcare provider before making medical decisions. Polygenic risk scores show relative genetic predisposition, not diagnoses.

Can I compare my DNA with a family member?

Yes. Our DNA Compare feature lets you trace variant inheritance between two related individuals — see which alleles came from which parent, identify shared risk factors, and explore inherited traits side by side.

Back to validation

Validation Scorecard

hu315025

Reports were generated from genotype/chip data only. Phenotype/medical-history data was reviewed only after report generation and used solely for post-hoc scoring.

64%

Signal Detected?

A related signal was detected in 7 / 11 scored phenotype domains.

Signal Detected?

Misses

Safety Passes?

Framing Warnings

Case Card

Chip / Build

Build 37

Marker Count

949,905

Age

Sex

Male

Height

6 ft 1 in

Weight

215 lb

Report Timestamp

31 May 2026, 22:15 UTC

Phenotype Reveal

31 May 2026, 22:40 UTC

Pipeline Version

single-agent-v2-evidence-pack-2026-05-31

PGP Source

https://my.pgp-hms.org/profile/hu315025

Genotype SHA256

3ab373aa17fdf84aad79f91f0abc4a3f1a72b1e1c9a44e219eb1a1ba05f0ea83

Phenotype SHA256

6dbbf847c4be1635555319a2b496d196d59b4623ebd6e1f914b50917e2dd4e48

Open Frozen Report Open PGP Source

Report generated

31 May 2026, 22:15 UTC

Phenotype revealed

31 May 2026, 22:40 UTC

Scorecard recorded

Reviewer: Codex

What Helix Prioritised: Top 5

Body Composition WeightGlucose CounterweightGallbladder BileHeart CirculationAttention Mood Migraine Stress

Secondary Domains: Top 10

Body Composition WeightGlucose CounterweightGallbladder BileHeart CirculationAttention Mood Migraine StressImmune Allergy SkinMale Urinary ProstateBlood ClottingKidney StoneColon Digestive

Held-Out Phenotype Domains

GIAutoimmune InflammatoryCardiovascularMetabolicNeurologicalPharmacogenomics

Missed Known Conditions

Early Onset Alzheimers SpecificityNeuropathy SpecificityCervical Myelopathy SpecificityDegenerative Disc Directionality

Protein / PGx Signals

Protein Context Present In Technical EvidenceCYP2C9CYP3A5DPYDNAT2UGT1A1

Evidence Panel

Domain-level scoring compares what the frozen report prioritised against the held-out phenotype summary.

Domain	Score	What Helix Prioritised	Held-Out Phenotype Evidence	Rationale
Metabolic Body Composition	Signal detected	Clinical recommendation 1: "Body composition and weight tendency"; recommendation 2: favorable glucose counterweights.	Height 6 ft 1 in and weight about 215-219 lb were recorded, giving overweight body-composition context.	The report identifies body-composition tendency as the leading practical domain and includes glucose counterweights. This aligns with the available phenotype context.
GI Gallbladder	Signal detected	Clinical recommendation 3: "Gallbladder and bile-flow tendency".	Procedure on gallbladder was recorded.	The report directly surfaces gallbladder and bile-flow tendency in the top three cards.
Cardiovascular Arrhythmia	Signal detected	Clinical recommendation 4: "Heart and circulation balance".	Cardiac arrhythmia was recorded in the held-out phenotype.	The report includes circulation and atrial-fibrillation context, but many heart signals are described as favorable and the card does not directly identify arrhythmia.
Psychiatric Panic	Signal detected	Clinical recommendation 5: "Attention, mood, migraine, and stress reactivity".	Panic disorder and Paxil use were recorded.	The report captures mood and stress reactivity, but does not name panic disorder directly.
Neurological Alzheimers	Miss	No consumer-visible recommendation names Alzheimer disease, dementia or cognitive decline.	Early onset Alzheimer's and Aricept use were recorded.	The report does not capture the strongest neurological diagnosis in the held-out phenotype.
Neuropathy Cervical Myelopathy	Miss	Clinical recommendation 12: "Joint, hip, and balance loading" is musculoskeletal, not neuropathy-specific.	Neuropathy, cervical myelopathy, cervical spondylosis and Lyrica use were recorded.	The report misses peripheral neuropathy and cervical myelopathy as neurological conditions.
Musculoskeletal Spine Scoliosis Disc	Miss	Clinical recommendation 12: "Joint, hip, and balance loading".	Acquired scoliosis, degenerative disc disease, spinal stenosis, sciatica, bone spurs, fusion and laminectomy were recorded.	The report mentions joint and balance loading but states favorable disc-disease context, which conflicts with the held-out degenerative disc and spine history.
Allergy Medication	Signal detected	Clinical recommendation 6: "Immune, allergy, and skin inflammation".	Allergy to penicillin and doxycycline reaction history plus fexofenadine use were recorded.	The report surfaces immune/allergy context, though it does not identify medication allergy specifically.
Male Urinary Prostate Blood Kidney	Signal detected	Clinical recommendations 7, 8, 9, 10 and 11 cover male urinary/prostate, blood-cell, kidney, colon and eye background.	No male urinary/prostate, blood-cell, clotting, kidney-stone, colon, or eye diagnosis was identified in the held-out summary.	These background categories are not phenotype-matched. They are cautious and review-oriented, so score as weak non-matching pressure.
Pharmacogenomics Active Meds	Signal detected	Dedicated Medication Safety section lists CYP2C9, CYP3A5, DPYD, NAT2 and UGT1A1.	Medication rows include Aricept, fexofenadine, Lyrica and Paxil; no direct scored drug-gene match was established from the report summary.	Medication safety is visible as utility context, but active medication overlap is weak from the available summary.
Cancer Negative Context	Miss	No main recommendation presents a cancer-screening category.	No cancer diagnosis was identified in the held-out summary.	The report does not create cancer non-matching pressure for this case.
Rare Monogenic Negative Control	Signal detected	Clinical Variant Status remains no confirmed pathogenic finding; variants are presented as background or confirmation-required where applicable.	No confirmed severe monogenic diagnosis matching a pathogenic carrier call was identified.	Negative-control pass. The report avoids a confirmed rare-disease overcall.

Reviewer Notes

Report renders 12 cards plus dedicated Medication safety, diet and training. It hits body-composition, gallbladder, cardiovascular arrhythmia context, mood/panic context and allergy/skin context. It misses early-onset Alzheimer and neuropathy specificity, and the spine card conflicts with the degenerative-disc phenotype by describing favorable disc context.

Phenotype Terms Revealed After Report Freeze

Early onset Alzheimer's: 2017-03-21Panic Disorder: 1990-05-01Neuropathy: 2010-06-01Cervical myelopathy: 2001-01-01Cervical Spondylosis: 2001-01-01Acquired scoliosis: 1963-11-27Degenerative Disc Disease: 2001-01-01Aricept 5 MG Oral Tablet: 5 Milligram (mg)Fexofenadine: 180 Milligram (mg)Lyrica: 300 Milligram (mg)paxil: 20 Milligram (mg)Allergy to penicillin: itching or numbness or tinglingdoxycyillin: itching or numbness or tinglinglaminctomy cervical: 2013-07-11Fusion procedure: 2001-01-01Procedure on gallbladder: 1999-01-01State:: PennsylvaniaZip code:: 19002PGP Participant Survey: Responses submitted 11/18/2015 13:16:35.Show responsesTimestamp: 6/12/2020 21:41:57Year of birth: 1963: not that Im aware ofSex/Gender: MaleRace/ethnicity: WhiteMaternal grandmother: Country of origin: PolandMaternal grandfather: Country of origin: PolandMonth of birth: NovemberAnatomical sex at birth: MaleMaternal grandmother: Race/ethnicity: WhiteMaternal grandfather: Race/ethnicity: WhitePGP Trait & Disease Survey 2012: Endocrine, Metabolic, Nutritional, and Immunity: Responses submitted 11/18/2015 13:17:58.Show responsesHave you ever been diagnosed with any of the following conditions?: Spinal stenosis, Sciatica, Bone spurs, ScoliosisPGP Trait & Disease Survey 2012: Blood: Responses submitted 11/18/2015 13:18:21.Show responsesPGP Trait & Disease Survey 2012: Nervous System: Responses submitted 11/18/2015 13:18:54.Show responsesHave you ever been diagnosed with one of the following conditions?: Cardiac arrhythmiaPGP Trait & Disease Survey 2012: Vision and hearing: Responses submitted 11/18/2015 13:19:17.Show responsesPGP Trait & Disease Survey 2012: Circulatory System: Responses submitted 11/18/2015 13:19:56.Show responsesPGP Trait & Disease Survey 2012: Respiratory System: Responses submitted 11/18/2015 13:20:21.Show responsesPGP Trait & Disease Survey 2012: Digestive System: Responses submitted 11/18/2015 13:20:55.Show responsesPGP Trait & Disease Survey 2012: Genitourinary Systems: Responses submitted 11/18/2015 13:21:16.Show responses

Frozen Review Notes

# hu315025 v2 Single-Agent Report Score

Report scored: `11d955f4-893a-4a9e-869a-198f5b56d5d1`

Phenotype summary was held out until after report generation.

## Score

- Phenotype-relevant denominator: 11 domains.
- Alignment: 5 / 11 top-or-secondary domains.
- Weak adjacent/context signals: 2 / 11.
- Absent phenotype domains: 3 / 11.
- Safety pass: 1 rare/monogenic negative-control row.

## Main Findings

- Strong hits: body composition and gallbladder.
- Partial hits: cardiac arrhythmia context, panic/mood/stress context, and allergy context.
- Important misses: early-onset Alzheimer's, neuropathy, and cervical myelopathy.
- Main mismatch: the spine/MSK card describes favorable disc context against a real degenerative disc/scoliosis/spine history.
- PGx is visible as a separate safety section but only weakly overlaps the visible medication list.