Validation
Blinded Phenotype-Domain Alignment
Reports were generated from genotype/chip data only. Phenotype/medical-history data was reviewed only after report generation and used solely for post-hoc scoring.
Public display rule: all eligible completed cases are shown, favorable or unfavorable.
91%
Signal Detected?
150 / 165 phenotype-relevant scored domains.
Signal detected means a related phenotype-domain signal was surfaced in a frozen genotype-only report. It does not mean diagnosis-level prediction or clinical accuracy.
Blinded genotype-only validation
A compact proof surface for reviewers: reports were generated from DNA/chip data first, then phenotype notes were opened afterward for scoring.
20 blinded cases
genotype-only reports
150 / 165
scored domains surfaced
Signal detection
not clinical accuracy
Phenotype held out
reports generated first
1
Blinded report generated first
The report is produced from genotype/chip data only.
2
Phenotype opened after
Medical-history files are held out until output artifacts are frozen.
3
Scorecard created afterward
Detected signals, misses, and framing/safety checks are recorded after phenotype reveal.
20
Eligible Cases
pilot_20_rerun
20
Completed Reports
0 queued
150
Signal Detected?
150 / 165 scored domains
15
Misses
19
Safety Passes?
0
Framing Warnings
Calibration Signals
Domains are grouped by whether the frozen report surfaced a related signal, missed it, or passed a safety-control row.
37 domains with calibration signal
| Domain | Denom. | Signal Detected ? | Misses | Safety Pass ? |
|---|---|---|---|---|
| GI / Digestive | 35 | 31 | 4 | 0 |
| Pharmacogenomics | 17 | 13 | 4 | 0 |
| Metabolic / Glycemic | 9 | 7 | 2 | 0 |
| Cancer | 18 | 17 | 1 | 0 |
| Musculoskeletal / Spine | 10 | 9 | 1 | 0 |
| Dental Cavities | 1 | 0 | 1 | 0 |
| Metabolic Body Size | 1 | 0 | 1 | 0 |
| Neurological | 1 | 0 | 1 | 0 |
| Cardiovascular / Vascular | 19 | 19 | 0 | 0 |
| Allergy / Dermatology | 12 | 12 | 0 | 0 |
| Renal / Uric Acid | 6 | 6 | 0 | 0 |
| Metabolic Body Composition | 3 | 3 | 0 | 0 |
| Immune / Inflammatory | 3 | 3 | 0 | 0 |
| Atopic Airway Sleep | 1 | 1 | 0 | 0 |
| Endometriosis Pelvic Pain | 1 | 1 | 0 | 0 |
| Heart Cholesterol Context | 1 | 1 | 0 | 0 |
| Psoriasis Skin Inflammation | 1 | 1 | 0 | 0 |
| Respiratory / Pneumonia | 1 | 1 | 0 | 0 |
| Urogenital UTI Ovarian Vulvar | 1 | 1 | 0 | 0 |
| Rare Monogenic Safety | 0 | 0 | 0 | 19 |
| Endocrine / Thyroid | 4 | 4 | 0 | 0 |
| Psychiatric / Mood | 3 | 3 | 0 | 0 |
| Metabolic / Body Composition | 2 | 2 | 0 | 0 |
| Vision / Eye | 2 | 2 | 0 | 0 |
| Blood / Iron Trait Context | 1 | 1 | 0 | 0 |
| Hematology MGUS Monoclonal Gammopathy | 1 | 1 | 0 | 0 |
| Hematology TTP Blood Cell | 1 | 1 | 0 | 0 |
| Iron Deficiency Anemia Blood Count | 1 | 1 | 0 | 0 |
| Male Reproductive Finasteride Context | 1 | 1 | 0 | 0 |
| Metabolic / Body Weight | 1 | 1 | 0 | 0 |
| Metabolic Body Weight | 1 | 1 | 0 | 0 |
| Ophthalmology Myopia Retina Cornea | 1 | 1 | 0 | 0 |
| Oral Ulcers Mouth Gut | 1 | 1 | 0 | 0 |
| Respiratory / Airway And Sleep | 1 | 1 | 0 | 0 |
| Respiratory Asthma Pneumonia | 1 | 1 | 0 | 0 |
| Respiratory Current Smoking Cough Wheeze | 1 | 1 | 0 | 0 |
| Skin / Contact Dermatitis | 1 | 1 | 0 | 0 |
Completed Cases
Each card links the frozen report, post-hoc scorecard, and original PGP source profile.
pgp-domain-prioritization-v2-rerun
hu315025
genotype-onlySignal64% (7/11)?Miss4Safety1?
Age56SexMaleHeight6 ft 1 inWeight215 lb
huA5BA2A
genotype-onlySignal100% (7/7)?Miss0Safety1?
Age60SexMaleHeight6 ft 3 inWeight245 lb
hu7B4393
genotype-onlySignal89% (8/9)?Miss1Safety1?
Age40SexMaleHeight5 ft 10 inWeight165 lb
huF7A4DE
genotype-onlySignal64% (7/11)?Miss4Safety1?
Age47SexFemaleHeight5 ft 7 inWeight138 lb
huB4E868
genotype-onlySignal73% (8/11)?Miss3Safety1?
Age39SexFemaleHeight5 ft 11 inWeight160 lb
hu57C9FD
genotype-onlySignal100% (9/9)?Miss0Safety1?
Age08-12SexMaleHeight5 ft 10 inWeight162 lb
hu50B3F5
genotype-onlySignal100% (8/8)?Miss0Safety1?
Age35SexFemaleHeight5 ft 11 inWeight180 lb
hu54EEB2
genotype-onlySignal100% (7/7)?Miss0Safety1?
Age02-05SexFemaleHeight5 ft 6 inWeight200 lb
hu6ED94A
genotype-onlySignal100% (5/5)?Miss0Safety1?
Age08-05SexMaleHeight5 ft 7 inWeight128 lb
hu6B7829
genotype-onlySignal100% (7/7)?Miss0Safety1?
Age53SexFemaleHeight5 ft 5 inWeight140 lb
huDBDF82
genotype-onlySignal100% (9/9)?Miss0Safety1?
Age07-19SexFemaleHeight5 ft 1 inWeight140 lb
huADB22D
genotype-onlySignal100% (9/9)?Miss0Safety1?
Age71SexMaleHeight5 ft 9 inWeight184 lb
huE9E777
genotype-onlySignal100% (7/7)?Miss0Safety1?
Age10-11SexMaleHeight5 ft 9 inWeight174 lb
hu30888B
genotype-onlySignal100% (10/10)?Miss0Safety0?
Age10-09SexMaleHeight5 ft 8 inWeight255 lb
hu7DE7FD
genotype-onlySignal100% (7/7)?Miss0Safety1?
Age03-14SexFemaleHeight5 ft 1 inWeight99 lb
hu5FCE15
genotype-onlySignal100% (7/7)?Miss0Safety1?
Age02-15SexMaleHeight5 ft 11 inWeight145 lb
hu3CAB43
genotype-onlySignal100% (6/6)?Miss0Safety1?
Age11-30SexMaleHeight5 ft 6 inWeight115 lb
Candidate Queue
These are eligible PGP candidates selected before phenotype-domain scoring.
| Dataset ID | Build | Markers | Medical Rows | Age | Sex | Height | Weight | Phenotype Domains | PGP Source | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| hu5BB600 | 37 | 949,904 | 143 | 37 | Male | — | — | 6 | PGP profile | Scored |
| hu315025 | 37 | 949,905 | 110 | 56 | Male | 6 ft 1 in | 215 lb | 6 | PGP profile | Scored |
| huA5BA2A | 37 | 949,904 | 75 | 60 | Male | 6 ft 3 in | 245 lb | 6 | PGP profile | Scored |
| hu7B4393 | 37 | 949,905 | 111 | 40 | Male | 5 ft 10 in | 165 lb | 7 | PGP profile | Scored |
| huF7A4DE | 37 | 620,634 | 102 | 47 | Female | 5 ft 7 in | 138 lb | 6 | PGP profile | Scored |
| hu05F442 | 37 | 949,904 | 124 | 60-69 | Female | — | — | 6 | PGP profile | Scored |
| huB4E868 | 37 | 949,904 | 106 | 39 | Female | 5 ft 11 in | 160 lb | 6 | PGP profile | Scored |
| hu57C9FD | 37 | 960,613 | 88 | 08-12 | Male | 5 ft 10 in | 162 lb | 6 | PGP profile | Scored |
| hu50B3F5 | 37 | 620,639 | 82 | 35 | Female | 5 ft 11 in | 180 lb | 3 | PGP profile | Scored |
| hu8550FF | 37 | 620,662 | 52 | 63 | Female | — | — | 3 | PGP profile | Scored |
| hu54EEB2 | 37 | 552,956 | 118 | 02-05 | Female | 5 ft 6 in | 200 lb | 6 | PGP profile | Scored |
| hu6ED94A | 37 | 571,875 | 131 | 08-05 | Male | 5 ft 7 in | 128 lb | 5 | PGP profile | Scored |
| hu6B7829 | 37 | 553,751 | 115 | 53 | Female | 5 ft 5 in | 140 lb | 6 | PGP profile | Scored |
| huDBDF82 | 37 | 552,961 | 89 | 07-19 | Female | 5 ft 1 in | 140 lb | 6 | PGP profile | Scored |
| huADB22D | 37 | 552,961 | 90 | 71 | Male | 5 ft 9 in | 184 lb | 5 | PGP profile | Scored |
| huE9E777 | 37 | 949,905 | 180 | 10-11 | Male | 5 ft 9 in | 174 lb | 8 | PGP profile | Scored |
| hu30888B | 36 | 956,734 | 172 | 10-09 | Male | 5 ft 8 in | 255 lb | 7 | PGP profile | Scored |
| hu7DE7FD | 36 | 950,749 | 162 | 03-14 | Female | 5 ft 1 in | 99 lb | 8 | PGP profile | Scored |
| hu5FCE15 | 36 | 956,728 | 147 | 02-15 | Male | 5 ft 11 in | 145 lb | 6 | PGP profile | Scored |
| hu3CAB43 | 36 | 950,748 | 139 | 11-30 | Male | 5 ft 6 in | 115 lb | 6 | PGP profile | Scored |